Description
This Southern-style meatloaf is moist, flavorful, and finished with a sweet and tangy glaze. A nostalgic comfort food favorite just like Nana used to make—perfect for Sunday dinners, meal prep, or weeknight family meals.
Who Is This Recipe For?
This recipe is perfect for:
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Home cooks craving down-home Southern comfort food
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Busy families needing a hearty, make-ahead dinner
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Anyone who grew up loving classic meatloaf
⭐ Why It’s Great
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Easy to make with pantry staples
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Moist texture and bold seasoning
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Signature ketchup-brown sugar glaze
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Leftovers make amazing sandwiches
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A family-favorite recipe that never fails
Kitchen Equipment Needed
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Large mixing bowl
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Loaf pan or baking sheet
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Small bowl for glaze
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Measuring cups/spoons
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Oven
Ingredients
Meatloaf:
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2 lbs ground beef (80/20)
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1 cup breadcrumbs
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1 medium onion, finely chopped
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2 garlic cloves, minced
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¼ cup milk
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2 large eggs
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1 tbsp Worcestershire sauce
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1 tsp salt
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½ tsp black pepper
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½ tsp dried thyme
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½ tsp dried oregano
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½ tsp smoked paprika
Glaze:
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½ cup ketchup
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2 tbsp brown sugar
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1 tbsp Dijon mustard
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1 tbsp apple cider vinegar
Instructions
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Preheat oven to 350°F (175°C). Grease a loaf pan or line a baking sheet.
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Mix meatloaf: In a large bowl, combine all meatloaf ingredients. Mix gently until just combined.
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Shape: Form into a loaf and place in pan or on baking sheet.
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Make glaze: Whisk ketchup, brown sugar, mustard, and vinegar in a small bowl.
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Bake: Spread half the glaze over the meatloaf. Bake 1 hour. Add remaining glaze and bake another 15–20 minutes, or until internal temp reaches 160°F (71°C).
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Rest: Let meatloaf rest 10 minutes before slicing.
Storage
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Refrigerate: Store leftovers in airtight container for up to 4 days
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Freeze: Wrap tightly and freeze up to 3 months
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Reheat: Reheat slices in oven or microwave with a splash of broth for moisture
❓ FAQ
Can I use ground turkey or chicken?
Yes, but reduce cooking time slightly and be cautious not to dry it out.
What breadcrumbs work best?
Plain or seasoned, or substitute with crushed crackers or oats.
Can I make it ahead of time?
Yes! Prepare the loaf, refrigerate overnight, and bake the next day.
Conclusion
Southern Nana’s Meatloaf is the kind of timeless recipe that fills the house with warmth and your plate with comfort. With a rich glaze and savory spices, it’s a satisfying main dish that brings everyone to the table.
